Isopropylamine Dodecylbenzenesulfonate

The Food and Drug Administration (FDA) includes Sodium Dodecylbenzenesulfonate on its list of secondary direct food additives. It is allowed to be used to assist in the peeling of fruits and vegetables. The FDA permits the salts of n-alkylbenzenesulfonic acid (including Ammonium Dodecylbenzenesulfonate, Calcium Dodecylbenzenesulfonate, Magnesium Isododecylbenzenesulfonate, Potassium Dodecylbenzenesulfonate, Sodium Decylbenzenesulfonate, Sodium Dodecylbenzensulfonate and Sodium Tridecylbenzenesulfonate) to be used as indirect food additives as emulsifiers and/or surface active agents as components of non-food articles. The safety of Ammonium Dodecylbenzenesulfonate, Calcium Dodecylbenzenesulfonate, DEA-Dodecylbenzenesulfonate, Isopropylamine Dodecylbenzenesulfonate, Magnesium Isododecylbenzenesulfonate, MIPA-Dodecylbenzenesulfonate, Potassium Dodecylbenzenesulfonate, Sodium Decylbenzenesulfonate, Sodium Dodecylbenzensulfonate, Sodium Tridecylbenzenesulfonate, TEA-Dodecylbenzenesulfonate and TEA-Tridecylbenzenesulfonate has been assessed by the Cosmetic Ingredient ReviewThe Cosmetic Ingredient Review (CIR) was established in 1976 as an independent safety review program for cosmetic ingredients. The CIR Expert Panel consists of independent experts in dermatology, toxicology, pharmacolgy and veterinary medicine. The CIR includes participation by the U.S. Food & Drug Administration and the Consumer Federation of America. (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that these ingredients were safe as ingredients in cosmetics and personal care products in the present practices of use when formulated to be non-irritating.

CIR Safety Review:

Linear alkylbenzenesulfonate was not a reproductive toxicant following dermal exposure. Sodium Dodecylbenzenesulfonate was not genotoxic or a carcinogen. Depending on the conditions, including concentration and formulation the linear alkylbenzenesulfonates including Ammonium Dodecylbenzenesulfonate, Calcium Dodecylbenzenesulfonate, DEA-Dodecylbenzenesulfonate, Isopropylamine Dodecylbenzenesulfonate, Magnesium Isododecylbenzenesulfonate, MIPA-Dodecylbenzenesulfonate, Potassium Dodecylbenzenesulfonate, Sodium Decylbenzenesulfonate, Sodium Dodecylbenzensulfonate, Sodium Tridecylbenzenesulfonate, TEA-Dodecylbenzenesulfonate and TEA-Tridecylbenzenesulfonate can be irritating to the skin.

The irritant properties of these ingredients are similar to those of other detergents, with the severity of irritation dependent on the concentration and pHA measurement of the acidity or basicity of a substance. pH is the negative logarithm (base 10) of the concentration of hydrogen ions in solution. Water has a concentration of hydrogen ions of 1.0 x 10-7, and thus has a pH of 7. A pH of 7 is considered neutral, a pH lower than 7 is considered acidic, and a pH higher than 7 is considered basic. of the product. Base on the potential of these ingredients to be irritating, the CIR Expert Panel concluded that Ammonium Dodecylbenzenesulfonate, Calcium Dodecylbenzenesulfonate, DEA-Dodecylbenzenesulfonate, Isopropylamine Dodecylbenzenesulfonate, Magnesium Isododecylbenzenesulfonate, MIPA-Dodecylbenzenesulfonate, Potassium Dodecylbenzenesulfonate, Sodium Decylbenzenesulfonate, Sodium Dodecylbenzensulfonate, Sodium Tridecylbenzenesulfonate, TEA-Dodecylbenzenesulfonate and TEA-Tridecylbenzenesulfonate were safe as ingredients in cosmetics and personal care products in the present practices of use when formulated to be non-irritating.

FDA Code of Federal Regulations for Sodium Dodecylbenzenesulfonate

FDA Code of Federal Regulations for n-alkylbenzenesulfonic acid and its salts

Ammonium Dodecylbenzenesulfonate, Calcium Dodecylbenzenesulfonate, Isopropylamine Dodecylbenzenesulfonate, Magnesium Isododecylbenzenesulfonate, Potassium Dodecylbenzenesulfonate, Sodium Decylbenzenesulfonate, Sodium Dodecylbenzensulfonate and Sodium Tridecylbenzenesulfonate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European UnionUnder the general provisions of the cosmetics regulation of the EU, ingredients appearing on the following function-specific annexes must comply with the listed restrictions and/or specifications: colorants (Annex IV), preservatives (Annex V), UV filters (Annex VI) and other ingredients with specific concentration limits and/or other restrictions (Annex III). Ingredients specifically prohibited from use in cosmetic products are listed in Annex II. Other ingredients listed in the EU cosmetic ingredient database (CosIng) may be used without restrictions.. MIPA-Dodecylbenzenesulfonate may be used in cosmetic products in Europe if the level of secondary amine in the ingredient is less than 0.5% (see Annex III). In Europe, the level of TEA in products is limited to 2.5% when TEA or TEA salts, such as TEA-Dodecylbenzenesulfonate or TEA-Tridecylbenzenesulfonate are added to a product (see Annex III). Ingredients containing diethanolamine (DEA) such as DEA-Dodecylbenzenesulfonate are not permitted for use in cosmetic products in Europe (see Annex II).

EU Cosmetic Regulation