Cetethyl Morpholinium Ethosulfate

What Is It?

Cetethyl Morpholinium Ethosulfate is an amber, waxy solid. In cosmetics and personal care products, Cetethyl Morpholinium Ethosulfate may be used in hair care products.

Why Is It Used?

Cetethyl Morpholinium Ethosulfate prevents or inhibits the buildup of static electricity and acts as a surfactantAn ingredient that helps two substances that normally do not mix to become dissolved or dispersed in one another. Also called a surface active agent. that helps to form emulsions by reducing the surface tension of the substances to be emulsified.

Scientific Facts

Cetethyl Morpholinium Ethosulfate is a quaternary ammonium salt. The quaternary nitrogen atom in these compounds always carries a cationic charge regardless of the pHA measurement of the acidity or basicity of a substance. pH is the negative logarithm (base 10) of the concentration of hydrogen ions in solution. Water has a concentration of hydrogen ions of 1.0 x 10-7, and thus has a pH of 7. A pH of 7 is considered neutral, a pH lower than 7 is considered acidic, and a pH higher than 7 is considered basic. of the system.

Safety Information

The Food and Drug Administration (FDA) includes 4-ethyl-4-hexadecyl morpholinium ethyl sulfate (Cetethyl Morpholinium Ethosulfate) on its list of indirect food additives. It may be used as a lubricant in the manufacture of polymers to be used as filters and repeat use textiles. The safety of Cetethyl Morpholinium Ethosulfate has been assessed by the Cosmetic Ingredient ReviewThe Cosmetic Ingredient Review (CIR) was established in 1976 as an independent safety review program for cosmetic ingredients. The CIR Expert Panel consists of independent experts in dermatology, toxicology, pharmacolgy and veterinary medicine. The CIR includes participation by the U.S. Food & Drug Administration and the Consumer Federation of America. (CIR) Expert Panel. The CIR Expert Panel reviewed the scientific data and concluded that the data were insufficient to assess the safety of Cetethyl Morpholinium Ethosulfate for use in cosmetic and personal care products.

CIR Safety Review: Cetethyl Morpholinium Ethosulfate was shown to be a severe ocular irritant. No additional relevant information was identified. Based on this lack of data, the CIR Expert Panel concluded that the data were insufficient to assess the safety of Cetethyl Morpholinium Ethosulfate as it is used in cosmetics and personal care products. Additional information requested included concentration of use, impurity information (especially information on nitrosamines), skin penetration, genotoxicity data and dermal irritation and sensitization data.

More information about nitrosamines.

Link to FDA Code of Federal Regulations for Cetethyl Morpholinium Ethosulfate

Cetethyl Morpholinium Ethosulfate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European UnionUnder the general provisions of the cosmetics regulation of the EU, ingredients appearing on the following function-specific annexes must comply with the listed restrictions and/or specifications: colorants (Annex IV), preservatives (Annex V), UV filters (Annex VI) and other ingredients with specific concentration limits and/or other restrictions (Annex III). Ingredients specifically prohibited from use in cosmetic products are listed in Annex II. Other ingredients listed in the EU cosmetic ingredient database (CosIng) may be used without restrictions..

Link to the EU Cosmetic Regulation:
http://europa.eu/legislation_summaries/consumers/product_labelling_and_p…

More Scientific Information

Other names for Cetethyl Morpholinium Ethosulfate include Cetyl Ethyl Morpholinium Ethosulfate, 4-Ethyl-4-Hexadecylmorpholinium Ethyl Sulfate and Quaternium-25.

Resources

Search the Code of Federal Regulations http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm

EU Cosmetics Inventory http://ec.europa.eu/consumers/cosmetics/cosing/