Aluminum Zirconium Pentachlorohydrex GLY

What Is It?

Aluminum Zirconium Trichlorohydrex GLY, Aluminum Zirconium Tetrachlorohydrex GLY, Aluminum Zirconium Pentachlorohydrex GLY and Aluminum Zirconium Octachlorohydrex GLY occur as a solids. These ingredients are complexes of Aluminum Zirconium Chlorohydrex (3, 4, 5 or 8 units) with glycine. These ingredients are used mainly in the formulation of personal cleanliness products.

Why Is It Used?

Aluminum Zirconium Trichlorohydrex GLY, Aluminum Zirconium Tetrachlorohydrex GLY, Aluminum Zirconium Pentachlorohydrex GLY, and Aluminum Zirconium Octachlorohydrex GLY are ingredients that are applied to the skin to reduce the production of perspiration at the site of application, to induce a tightening or tingling sensation of the skin and to reduce or eliminate unpleasant odor.

Scientific Facts

Aluminum Zirconium Trichlorohydrex GLY, Aluminum Zirconium Tetrachlorohydrex GLY, Aluminum Zirconium Pentachlorohydrex GLY, and Aluminum Zirconium Octachlorohydrex GLY are complexes of an inorganic and an organic compound. GLY is an abbreviation for the amino acid glycine.

Safety Information

The Food and Drug Administration (FDA) has reviewed the safety of the Aluminum Zirconium Chlorohydrex GLY ingredients and has approved these ingredients for use as ingredients in Over-the-Counter (OTC) antiperspirant drug products. Cosmetic Ingredient Review (CIR) has deferred evaluation of these ingredients because the safety has been assessed by FDA. This deferral of review is according to the provisions of the CIR Procedures.

More information about aluminum

More information about the safety of antiperspirant OTC drug products.

FDA Code of Federal Regulations for antiperspirant active ingredients including the Aluminum Zirconium Chlorohydrex complexes with glycine

In Europe, the uses of Aluminum Zirconium Chlorohydrate complexes with glycine are restricted to antiperspirant products according to the Cosmetics Directive of the European Union (see Appendix III).

In Canada, the use of zirconium compounds in cosmetics and personal care products, including the Aluminum Zirconium Chlorohydrex complexes with glycine, is regulated.

 

More Scientific Information

Aluminum Zirconium Chlorohydrex GLY compounds are coordination complexes of Aluminum Zirconium Chlorohydrate (3, 4, 5, or 8 units) and glycine in which some of the water molecules normally coordinated to the metal have been displaced by glycine.

Resources

Find out more about the regulation of over-the-counter drugs by the Food and Drug Administration