Expert Panel for Cosmetic Ingredient Safety:
The safety of 4-Amino-2-hydroxytoluene has been assessed by the Expert Panel for Cosmetic Ingredient Safety. The Expert Panel evaluated the scientific data and concluded that 4-amino-2-hydroxytoluene was safe as used in hair dye products. In 2006, as part of the scheduled re-evaluation of ingredients, the Expert Panel considered available new data on 4-amino-2-hydroxytoluene and reaffirmed the above conclusion.
4-Amino-2-hydroxytoluene was poorly absorbed through the skin. In addition, 4-amino-2- hydroxytoluene had low oral toxicity and had no significant mutagenic or developmental effects. 4-Amino-2-hydroxytoluene demonstrated a weak potential for sensitization and was negative in photosensitization tests. A variety of epidemiology studies have given no indication of a carcinogenic effect from the use of hair dyes. The weight of the epidemiological evidence supports the safety of hair dyes.
More information about the safety of hair dyes.
In the European Union, 4-amino-2-hydroxytoluene may be used in hair dye products at a maximum concentration of 1.5% after mixing with hydrogen peroxide (see Annex III). Products containing 4-amino-2-hydroxytoluene must be labeled as indicated in Annex III.