Isoamyl p-Methoxycinnamate

What Is It?

Isoamyl p-Methoxycinnamate is an organic compound that absorbs ultraviolet (UV) light.

Why Is It Used?

In Europe, Isoamyl p-Methoxycinnamate is an approved UV filter, which means the ingredient can be added to sunscreen products that are designed to protect the skin from the sun. In Europe, sunscreen products are considered cosmetic products. In the United States, sunscreen products are Over-the-Counter (OTC) drugs and only certain ingredients have been approved by the Food and Drug Administration (FDA) for use in these products. In assessing sunscreen active ingredients, the FDA reviews both safety and efficacy. The safety and efficacy of Isoamyl p-Methoxycinnamate has not yet been reviewed for sunscreen use by the FDA and it cannot be used in sunscreen drug products. For cosmetics in the United States, Isoamyl p-Methoxycinnamate can be used as a UV light absorber. In this case, the ingredient serves to protect the product from deterioration by absorbing, reflecting, or scattering UV light.

Scientific Facts

Isoamyl p-Methoxycinnate, also referred to as Amiloxate, absorbs UV radiation which is an important cause of premature aging of the skin and in the development of melanoma and other forms of skin cancer.

Safety Information

The European Commission’s Scientific Committee on Cosmetology (SCC) conducted a safety evaluation of Isoamyl p-Methoxycinnamate. Based on their review, they concluded that use of this ingredient in cosmetic products as a UV light absorber at a maximum concentration of 10% would not pose a health hazard.

The European SCC concluded that Isopentyl p-Methoxycinnamate (Isoamyl p-Methoxycinnamate) was not irritating or allergenic. It was not genotoxic and was not associated with reproductive effects.

Link to the European Commission’s SCC opinion concerning Isopentyl p-Methoxycinnamate:…

Isoamyl p-Methoxycinnamate (mixture of isomers) is listed in the Cosmetics Directive of the European Union and may be used as a UV filter in cosmetics and personal care products at a maximum concentration of 10% (see Annex VII).

Link to the EU Cosmetic Regulation:

More Scientific Information

Isoamyl p-Methoxycinnamate is the ester of isoamyl alcohol (also called isopentyl alcohol) and p-methoxycinnamic acid. In cosmetics and personal care products, Isoamyl p-Methoxycinnamate functions as a UV light absorber. UV absorbers, like sunscreen agents, have the ability to convert UV radiation into less damaging infrared radiation (heat).


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EU Cosmetics Inventory