The safety of adipic acid dihydrazide has been assessed by the Expert Panel for Cosmetic Ingredient Safety. The Expert Panel evaluated the scientific data and concluded that the available data were insufficient to determine the safety of adipic acid dihydrazide as used in cosmetics and personal care products.

Adipic acid dihydrazide was previously reported to be used; however, there were no reported uses of adipic acid dihydrazide in 1992 at the time of the Expert Panel evaluation. The available safety test data were insufficient to judge the safety of use of adipic acid dihydrazide in cosmetics and personal care products. The types of data required before an evaluation on the safety of use of this cosmetic ingredient include: metabolism (stability of compound, with respect to hydrolysis to hydrazine), stability and impurities (specifically data on hydrazine content is necessary) and concentration of use in cosmetic formulations.

Hydrazides and their salts, including adipic acid dihydrazide, must not form part of the composition of cosmetics and personal care products marketed in the European Union (see Annex II).

Health Canada does not permit the use of hydrazides and their salts in cosmetics and personal care products.