The CIR Expert Panel evaluated the scientific data and concluded that these ingredients were safe for use as hair dye ingredients.
CIR Safety Review:
The CIR Expert Panel reviewed data indicating that less than 2% of 2-Amino-4-Hydroxyethylaminoanisole Sulfate in a hair dye formulation penetrated the skin. A repeat oral dose study of 2-Amino-4-Hydroxyethylaminoanisole Sulfate at exposures higher than would be expected from the use of a hair dye resulted in no adverse effects.
2-Amino-4-Hydroxyethylaminoanisole Sulfate was not a reproductive or developmental toxicant, and it was not considered genotoxic. At concentrations used in hair dyes, 2-Amino-4-Hydroxyethylaminoanisole Sulfate was not irritating nor did it cause skin sensitization.
According to the U.S. Food, Drug and Cosmetic Act, hair dyes are not subject to approval by FDA but are required to bear a caution statement and appropriate “patch test” instructions for determining whether the product causes skin irritation in the user.
Patch test instructions call for a 24 hour patch on the skin of the user with the color solution and hydrogen peroxide mixed in the same manner as in use conditions. This test is to be performed prior to each and every application of the hair dye.
2-Amino-4-Hydroxyethylaminoanisole and 2-Amino-4-Hydroxyethylaminoanisole Sulfate are listed in the Cosmetics Directive of the European Union and may be used as oxidizing coloring agents for hair dying at a maximum concentration of 1.5% (as the sulfate) when combined with hydrogen peroxide (see Annex III). Hair dye products containing these ingredients must be labeled as indicated in Annex III.
Link to the EU Cosmetic Regulation: http://europa.eu/legislation_summaries/consumers/product_labelling_and_packaging/co0013_en.htm
More information about the safety of hair dyes.