Methyl Nicotinate

What Is It?

Methyl Nicotinate is an ester of methyl alcohol and nicotinic acid. In cosmetics and personal care products, Methyl Nicotinate is used in the formulation of face and neck products.

Why Is It Used?

Methyl Nicotinate enhances the appearance of dry or damaged skin by reducing flaking and restoring suppleness. In OTC drug products, it can also relieve pain when applied to the skin.

Scientific Facts

Methyl Nicotinate is derived from nicotinic acid, or niacin, a water-soluble vitamin. Niacin is essential for energy metabolism, hormone production, and DNA repair.

Safety Information

The Food and Drug Administration (FDA) reviewed the safety of Methyl Nicotinate and approved its use as an ingredient in Over-the-Counter (OTC) external analgesics. Cosmetic Ingredient Review (CIR) has deferred evaluation of this ingredient because the safety has been assessed by the Food and Drug Administration (FDA). This deferral of review is according to the provisions of the CIR Procedures.

The Joint FAO/WHO Expert Committee on Food Additives has not limited the Acceptable Daily Intake of Methyl Nicotinate for humans. No safety concern is present at current levels of intake when Methyl Nicotinate is used as a flavoring agent.
http://www.inchem.org/documents/jecfa/jeceval/jec_1531.htm

In the United Stated, Methyl Nicotinate may be used in OTC external analgesics as a counter irritant. http://www.fda.gov/cder/otcmonographs/External_Analgesic/ext_analgesic_T…

Methyl Nicotinate may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union.

Link to the EU Cosmetic Regulation: 
http://europa.eu/legislation_summaries/consumers/product_labelling_and_p…

More Scientific Information

Methyl Nicotinate is the ester of methyl alcohol and nicotinic acid. In cosmetics and personal care products, Methyl Nicotinate functions a skin conditioning agent – miscellaneous. It may be used in OTC drug products as an external analgesic.

Resources

Find out more about the regulation of over-the-counter drugs by the Food and Drug Administration

OTC Drug Home Page: http://www.fda.gov/Drugs/ResourcesForYou/Consumers/BuyingUsingMedicineSa…

Information about OTC Drug monographs: https://www.fda.gov/drugs/over-counter-otc-drug-monograph-process

Search the Code of Federal Regulations http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/cfrsearch.cfm

EU Cosmetics Inventory http://ec.europa.eu/consumers/cosmetics/cosing/