Aminomethyl Propanol
More safety information:
CIR Safety Review: The CIR Expert Panel noted that although pure Aminomethyl Propanol and Aminomethyl Propanediol are highly alkaline, when used in cosmetic products they are buffered, and the adverse effects observed with the pure compound are not observed.
In primary irritation studies, Aminomethyl Propanol and formulations containing Aminomethyl Propanol were, at most, minimally irritating to abraded and nonabraded skin. Cosmetics and personal care products containing Aminomethyl Propanediol were only minimally irritating to skin. Aminomethyl Propanol was not an skin sensitizer and products containing Aminomethyl Propanediol or Aminomethyl Propanol were minimal to moderate irritants to the eyes. Aminomethyl Propanol and Aminomethyl Propanediol were nonmutagenic, both with and without metabolic activation.
In clinical studies, Aminomethyl Propanol and Aminomethyl Propanediol were neither primary dermal irritants nor dermal sensitizers. Data were available to support the safety of these ingredients at a concentraiton of 7% for Aminomethyl Propanol and 2% for Aminomethyl Propandiol. The CIR Expert Panel noted that these ingredients may be contaminated with secondary amines which may form potentially carcinogenic nitrosamines. The CIR Expert Panel cautioned that if Aminomethyl Propanol and Aminomethyl Propanediol used in cosmetic products contain secondary amines, these ingredients should not be used in cosmetic formulations containing nitrosating agents.
More information about nitrosamines.
Link to FDA Code of Federal Regulations for Aminomethyl Propanol
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRS...
Aminomethyl Propanol and Aminomethyl Propanediol are monoalkanolamines. Monoalkylamines, monoalkanolamines and their salts are listed in the Cosmetics Directive of the European Union (Annex III, Part I). These ingredients are permitted for use in cosmetics and personal care products when they have a purity of 99%, a maximum secondary amine content of 0.5%, and a maximum nitrosamine content of 50 microg/kg. Aminomethyl Propanol and Aminomethyl Propanediol may not be used in products with nitrosating systems.
Link to the EU Cosmetics Directive: http://ec.europa.eu/consumers/sectors/cosmetics/documents/di...
In primary irritation studies, Aminomethyl Propanol and formulations containing Aminomethyl Propanol were, at most, minimally irritating to abraded and nonabraded skin. Cosmetics and personal care products containing Aminomethyl Propanediol were only minimally irritating to skin. Aminomethyl Propanol was not an skin sensitizer and products containing Aminomethyl Propanediol or Aminomethyl Propanol were minimal to moderate irritants to the eyes. Aminomethyl Propanol and Aminomethyl Propanediol were nonmutagenic, both with and without metabolic activation.
In clinical studies, Aminomethyl Propanol and Aminomethyl Propanediol were neither primary dermal irritants nor dermal sensitizers. Data were available to support the safety of these ingredients at a concentraiton of 7% for Aminomethyl Propanol and 2% for Aminomethyl Propandiol. The CIR Expert Panel noted that these ingredients may be contaminated with secondary amines which may form potentially carcinogenic nitrosamines. The CIR Expert Panel cautioned that if Aminomethyl Propanol and Aminomethyl Propanediol used in cosmetic products contain secondary amines, these ingredients should not be used in cosmetic formulations containing nitrosating agents.
More information about nitrosamines.
Link to FDA Code of Federal Regulations for Aminomethyl Propanol
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRS...
Aminomethyl Propanol and Aminomethyl Propanediol are monoalkanolamines. Monoalkylamines, monoalkanolamines and their salts are listed in the Cosmetics Directive of the European Union (Annex III, Part I). These ingredients are permitted for use in cosmetics and personal care products when they have a purity of 99%, a maximum secondary amine content of 0.5%, and a maximum nitrosamine content of 50 microg/kg. Aminomethyl Propanol and Aminomethyl Propanediol may not be used in products with nitrosating systems.
Link to the EU Cosmetics Directive: http://ec.europa.eu/consumers/sectors/cosmetics/documents/di...
More scientific information:
Aminomethyl Propanol and Aminomethyl Propanediol are substituted aliphatic alcohols. In cosmetics and personal care products, they both function as pH adjusters.
