PEG-5M
More safety information:
CIR Safety Review: The CIR Expert Panel noted that in general, the polyethylene glycol (PEG) ingredients have a low order of oral and dermal toxicity. Lower molecular weight PEG ingredients were minimally absorbed and higher molecular weight PEGs (PEG-75 and greater) were not absorbed through intact skin. The PEGs were minimally irritating to human skin, and were not sensitizers. The available data indicated that the PEGs were not mutagenic or carcinogenic.
During its first review of the PEG ingredients, the Expert CIR Panel reviewed studies which reported kidney toxicity in severely burned patients treated several times each day with a PEG-based antimicrobial cream. The PEG content of the antimicrobial cream was determined to be the causative agent. However, no evidence of systemic toxicity occurred in studies with intact skin. Additional penetration data reviewed during the second CIR review of the PEG ingredients indicated that penetration is only significantly increased when both the top layer and underlying layers of the skin are severely damaged, which occurs in second and third degree burns. Based on this new information, the CIR Expert concluded that the PEG ingredients are safe for use in cosmetic products.
Small amounts of 1,4-dioxane, a by-product of ethoxylation, may be found in polyethylene glycol ingredients including the polyethylene glycol ingredients. The potential presence of this material is well known and can be controlled through purification steps to remove it from the ingredients before blending into cosmetic formulations.
FDA: Link to Code of Federal Regulations for Triethylene Glycol
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRS...
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRS...
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRS...
Link to more information about 1,4-dioxane, including what the Food and Drug Administration (FDA) is doing to assure that cosmetics do not contain unsafe levels of 1,4-dioxane.
The PEG ingredients may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.
Link to the EU Cosmetics Directive: http://ec.europa.eu/consumers/sectors/cosmetics/documents/di...
During its first review of the PEG ingredients, the Expert CIR Panel reviewed studies which reported kidney toxicity in severely burned patients treated several times each day with a PEG-based antimicrobial cream. The PEG content of the antimicrobial cream was determined to be the causative agent. However, no evidence of systemic toxicity occurred in studies with intact skin. Additional penetration data reviewed during the second CIR review of the PEG ingredients indicated that penetration is only significantly increased when both the top layer and underlying layers of the skin are severely damaged, which occurs in second and third degree burns. Based on this new information, the CIR Expert concluded that the PEG ingredients are safe for use in cosmetic products.
Small amounts of 1,4-dioxane, a by-product of ethoxylation, may be found in polyethylene glycol ingredients including the polyethylene glycol ingredients. The potential presence of this material is well known and can be controlled through purification steps to remove it from the ingredients before blending into cosmetic formulations.
FDA: Link to Code of Federal Regulations for Triethylene Glycol
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRS...
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRS...
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRS...
Link to more information about 1,4-dioxane, including what the Food and Drug Administration (FDA) is doing to assure that cosmetics do not contain unsafe levels of 1,4-dioxane.
The PEG ingredients may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.
Link to the EU Cosmetics Directive: http://ec.europa.eu/consumers/sectors/cosmetics/documents/di...
More scientific information:
PEG ingredients are liquids or solids, depending on the molecular weights. Derivatives of PEG are also in common use in cosmetics. These include ingredients such as the Sorbeths, and other ingredients ending in -eth and a number.
