CIR Safety Review: The CIR Expert Panel noted that Tosylamide/Formaldehyde Resin was practically nontoxic when given orally as a 70% solution in acetone and when applied to the skin as a 40% suspension in corn oil. Tosylamide/Formaldehyde Resin in the form of a finely ground powder was nonirritating to skin and slightly irritating to the eye. The undiluted material was nonirritating to skin, slightly irritating to the eye, and practically nontoxic by dermal application. No significant treatment-related effects were observed in a subchronic oral study. Tosylamide/Formaldehyde Resin was negative in a bacterial test for mutagenicity.

In clinical studies, 10% Tosylamide/Formaldehyde Resin in dimethyl phthalate was nonirritating and nonsensitizing to the skin. Nail products containing up to 12% Tosylamide/Formaldehyde Resin were nonsensitizing, nonphotosensitizing and essentially nonirritating to human skin. Reports of nail polish dermatitis of allergic origin have been attributed to Tosylamide/Formaldehyde Resin and other liquid thermoplastic resins.

Link to FDA Code of Federal Regulations for Toluenesulfonamide-Formaldehyde http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRS...

Tosylamide/Formaldehyde Resin may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Directive of the European Union.
Link to the EU Cosmetics Directive: http://ec.europa.eu/consumers/sectors/cosmetics/documents/di...

Tosylamide/formaldehyde Resin, also referred to as Toluenesulfonamide/Formaldehyde Resin, is a reaction product of toluenesulfonamide and formaldehyde. It is an amorphous resin and is used in conjunction with the polymer nitrocellulose in nail enamel products. Tosylamide/Formaldehyde resin functions as a film former and plasticizer. It imparts high gloss and good flow properties and increases the hardness of nitrocellulose film. The purity and residual formaldehyde content are tightly controlled in resins used for in nail products with maximum levels of 0.5% formaldehyde and with typical levels at less than 0.2%.

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