The Food and Drug Administration (FDA) permits acetone to be used as in indirect food additive as a part of adhesives and as a component of food-contact coatings. The FDA permits small amounts of acetone to be present in spice oleoresins as a result of the extraction process.

FDA: Link to Code of Federal Regulations for acetone:

• Industrial Starch-Modified 
• Resinous and polymeric coatings for polyolefin films
• Acetone 

Acetone may be used in cosmetics and personal care products marketed in Europe according to the general provisions of the Cosmetics Regulation of the European Union.

As part of the Organization for Economic Cooperation and Development (OECD) High Production Volume (HPV) chemical program, safety information available on acetone was reviewed. The review noted that although acetone is not considered a skin irritant or sensitizer, its solvent action can result in the removal of fat from the skin following skin contact. acetone is an eye irritant. Dermal carcinogenicity studies were negative. The reviewers recommended that no additional studies on acetone be completed.